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Year : 2013  |  Volume : 1  |  Issue : 2  |  Page : 76-80

Effect of nilumbu nucifera in phenylhydrazine induced anaemia in rats

1 Department of pharmacology, P. Wadhwani College of Pharmacy, Yavatmal, (MS), India
2 Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, (MS), India

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The present study investigate the haematinic activity of an aqueous extract of Nilumbo nucifera leaves on phenylhydrazine induced anaemic rats. Anaemia was induced by an oral administration of phenylhydrazine 10 mg/kg for a period of 8 days. Red blood cell count (RBC), haemoglobin(Hb), and haematocrite (HCT), mean cell haemoglobin (MCH), mean cell volume (MCV), mean cell haemoglobin concentration (MCHC), White Blood cell count (WBC) and Platlet (PLT) were analyzed as indices of anaemia. The Phenylhydrazine induced a significant decrease (P<0.05) in the blood parameters indicating anaemia. The same groups were treated with leaf extract of Nilumbo nucifera (Dose 200 mg/kg and 400 mg/kg, orally) and Lauha bhasma (11 mg/kg). The extract of Nilumbo nucifera shows significant (P<0.05) increase in the RBC and Hb, which had been originally decreased by phenylhydrazine administration within one week of treatment. And the results suggested that Nilumbo nucifera leaves have haematinic properties. Extract of Nilumbo nucifera in combination with Lauha bhasma shows significant haematinic activity (P<0.05) as compared to the Nilumbo nucifera and Lauha bhasma alone. This study shows that Nilumbo nucifera have anti anaemic potential and even it gives the synergistic activity with Lauha bhasma.

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