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   Table of Contents - Current issue
Coverpage
October-December 2022
Volume 10 | Issue 4
Page Nos. 219-288

Online since Saturday, December 31, 2022

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EDITORIAL  

The need for an interdisciplinary strategy for a better quality of living Highly accessed article p. 219
Vaishali Vasant Kuchewar
DOI:10.4103/jism.jism_101_22  
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ORIGINAL ARTICLES Top

Pharmacognostical and physicochemical profile of Abhayadi Gutika: An polyherbal formulation Highly accessed article p. 221
Sunny C Patil, Arjun S Baghel, Shubhangi B Kamble, Harisha C Rudrappa, Vinay J Shukla, Mehul D Mehta
DOI:10.4103/jism.jism_68_22  
Introduction: Quality standardization and maintenance of these standards is the need of the hour in this era which is showing growing demand for traditional medicines. Although Abhayadi Gutika (AG) is an important formulation in Ayurvedic pharmacopeia, it lacks scientific documentation. Aims: The aim was to study organoleptic, microscopic, physicochemical, phytochemical, nutraceutical, and high-performance thin-layer chromatography (HPTLC) profile of AG. Materials and Methods: AG was prepared and subjected to pharmacognostical analysis in which organoleptic and microscopic characteristics were identified. This was followed by analytical study comprising physicochemical, phytochemical, neutraceutical parameters, acid-neutralizing capacity, and HPTLC profile. Results: Pharmacognostical microscopic evaluation revealed the presence of starch grains, acicular crystals, group of fibers, sclereids, stone cells, and epicarp cells. Quantitative physicochemical analysis revealed loss on drying value as 6.37% w/w, ash value as 2.16% w/w, water-soluble extractive value as 44.37% w/w, alcohol-soluble extractive value as 37.91% w/w, and pH value as 6.5. Phytochemical analysis showed the presence of flavonoids, saponins, and tannins in the finished product. In nutraceutical evaluation, functionalities such as total proteins (4.82%), total fats (0.5%), total carbohydrates (70.48%), total sugars (48%), and crude fibers (2.5%) were observed. Acid-neutralizing capacity for AG was found to be 1.3 meq/gm. HPTLC fingerprinting exhibited five peaks (Rf values: 0.18, 0.28, 0.72, 0.81, 0.84) at 254 nm, seven peaks (Rf values: 0.09, 0.22, 0.25, 0.28, 0.53, 0.58, 0.64) at 366 nm and two peaks (Rf values: 0.64, 0.72) at 540 nm on densitogram. Conclusion: Preliminary profiling of AG exhibited striking pharmacognostical as well as analytical characteristics. In nutraceutical analysis, functionalities like proteins, fats, carbohydrates, sugars and crude fibers were observed. Acid-neutralizing capacity which is a measure of efficacy of medicines prescribed for hyperacidity (antacids) was found to be 1.3 meq/gm for AG which supports its therapeutic efficacy in the disease conditions like Vidagdhajirna.
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REVIEW ARTICLES Top

A critical review of Vishaghna Dravya mentioned in Madanpal Nighantu p. 228
Chandradev Pandey, Amol Sudhakar Kadu, Anita Sharma, Narsingh Patel
DOI:10.4103/jism.jism_3_22  
Background: Agada Tantra is the branch of Ayurveda that deals with food poisoning, snakebites, dog bites, insect bites, etc. Envenoming is an important public health problem in India. In modern, there are various treatments including anti-venoms for poisoning. But still, there is a lacuna in treatment due to the side effect of contemporary treatment. But in Ayurveda, various drugs are described, having antitoxic properties, without any side effects. Aim: To provide comprehensive information about Vishaghna Dravya (anti-toxic drug) mentioned in Madanpal Nighantu which is used as a medicine for the treatment of different animate, inanimate poison, and metallic poison. Materials and Methods: Ayurveda text Madanpal Nighantu in Sanskrit as well as Hindi where the Dravya (drug) of different origins and their antitoxic property are mentioned have been referred for this literary work. Knowing the relevance of drugs in the form of Visha Chikitsa (treatment of poison) and their Vishaghna Guna (antitoxic property). For the discussion, all of the gathered information has been reorganized and critically reviewed, and an attempt has been made to draw certain meaningful insights. Results and Conclusion: In this article, we focused on various Vishahar Dravya mentioned in Madanpal Nighantu, based on Rasa, Guna, Virya, and Vipaka, and out of 500 drugs in Madanpal Nighantu there are 74 drugs having Vishaghna properties. This Nighantu generally describe drugs having action against different type of poisons such as Jangam, Sthavar, and Dhatu Visha. Visha-Upavisha Dravyas from the therapeutic point of view are considered highly valuable in accordance with their quick effectiveness even in smaller doses.
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The formulations in Rasayogsagar for treating toxicity: Critical review p. 234
Narayan Pandey, Anita Sharma, Amol S Kadu, Kishore Das, Naresh Itani, Saroj M Pokhrel
DOI:10.4103/jism.jism_50_22  
Background: In the current era, different toxicants are a major problem for human Owing to industrialization and civilization, people are embedded in the test-tube of toxins. Different kinds of toxicants, which are called xenobiotics, found in the form of chemicals, pesticides, coloring agents, and antibiotics, which enter into the body through different routes such as oral, dermal, and inhalation, play an important role as a etiological factor for the pathology of different diseases such as hypertension, diabetes mellitus, cancer, and so on. All these artificial poisons are considered to be Kritrim Visha, which are also called Gara Visha in Ayurveda, which is described to be one of the causative factors to cause disease conditions. So, it is necessary to identify those preparations or formulations which act as an anti-toxic action. The classical text, i.e., Rasayogsagar, has mentioned thousands of preparations, among them about 74 are Vishaghna Yoga (anti-toxic preparations) which have been specifically indicated either in animate or in inanimate toxicity or in both. These formulations in the modern era have a great importance to reduce the toxicity level in human beings. So, these preparations must be prepared and made available everywhere following the guidelines of preparation mentioned in Rasayogsagar, which could play to pacify the toxic substance and prevent the harmful effects in human beings. Aims and Objectives: The aim of this study is as follows: (i) To study the indication of different preparations mentioned in Rasayogsagar for different toxic manifestations. (ii) A detailed literary study of contents and methods of preparations of Vishaghna (anti-toxic) with doses and route of administration. Materials and Methods: The article is based on literary review regarding anti-toxic action (Vishaghna) of various kinds of preparations, which has been collected and compiled from Ayurvedic compendium (i.e., Rasayogsagar). Results and Conclusion: In total, 74 anti-toxic (Vishaghna) formulations have been found in Rasayogsagar. Most of them have found to be specifically indicated in anti-toxic action-specific (Visha Rogadhikar) and some of them have been indicated in other disease conditions but have anti-toxic properties (Vishaghna) also.
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External applications of Shigru (Moringa oleifera Lam): A comprehensive review p. 241
Swati K Gavadiya, Tarun Sharma, Vidhi M Bapna
DOI:10.4103/jism.jism_48_22  
Background: Plants are the main source of medicine in traditional system of medicines like Ayurveda. In Ayurvedic literature, there are indications of Basti (drug administration through anal route) and Nasya (drug administration through nasal route) along with oral route. Similarly, for external application, there were many forms such as lepa (external application of paste), Aschyotana (eye drops), Anjana (collyrium), etc. The Ayurveda literature is a treasure of many formulations that can be therapeutically used through various routes in Netra roga (eye disorders), Karna roga (ear disorders), Kustha (skin diseases), Apsmara (epilepsy), Galganda (goitre), and Slipada (elephantiasis). Systematic monographs of single drugs can be very useful for clinical application. Moringa oleifera is a single drug, which is abundantly available as well as therapeutically efficacious; this review is an appraisal to compile and present the external therapeutic uses of Shigru (Moringa oleifera Lam). Aim: The aim of the study was to review the Ayurvedic literature to collect information regarding the external therapeutic use of various parts of Shigru. Materials and Methods: Extensive review of Shigru involves the study of Veda, Samhita, Chikitsa granth, Ayurvedic compendia, and various databases like database of India, etc., regarding various formulations, dosage form, indications, and useful parts. Result: During the literature survey, a total of 149 formulations in 145 dosage forms of Shigru have been recommended for 24 diseases. Conclusions: Shigru is extensively useful for external application, and based on the information presented in this literature survey, it can be therapeutically used in many diseases as well as novel formulations and dosage forms using Shigru (Moringa oleifera Lam).
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Therapeutic indications of formulations of Kapardika Bhasma (Cowrie calx) described in bharat bhaishajya ratnakar p. 251
Pranjali Dukare, Bharat Jagdishaji Rathi, Anita Wanjari, Mujahid Khan
DOI:10.4103/jism.jism_60_22  
Introduction: Kapardika (Cypraeamoneta) is one of the animal origin drug mentioned in Rasashastra. According to different texts Kapardika (Cypraeamoneta) is classified under two categories they are Sudha Varga (Calcium component drugs) and Sadharana Rasa Varga (Herbal origin drug) Its medicinal usage is known since Vedic era and was used to treat various ailments effectively. Aim and Objective: Aim of the present study is to collect the formulations containing Kapardika Bhasma (Cypraeamoneta Powder) described in the text Bharat Bhaishajya Ratnakar and find out its therapeutic efficacy. Materials and Methods: All the formulations containing Kapardika bhasma (Cypraeamoneta Powder) are reviewed from all the five volumes of Bharat Bheshaja Ratnakar and again categorized according to its dosage forms. Observation and Results: Total 42 formulations containing Kapardika Bhasma (Cypraeamoneta Powder) have been reviewed which are indicated in Agnimandya (Loss of appetite), Parinamshula (Duodenal ulcer), Grahani (Malabsorption syndrome), Rajaykshma (Tuberculosis), Karnasrava (Ottorhoea), Netraroga (Diseases of the eye), and Sukraksaya (Oligospermia). These formulations are advised to be taken in different dosage forms such as Anjana (Collyrium) Vati (Tablets), Pottali (Bundle) etc. Conclusion: The present work will be valuable in recognition of newer formulations of Kapardika Bhasma (Cypraeamoneta Powder) and their therapeutic applications in various ailments.
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Low back pain: the riveting history with unexplored ancient Indian knowledge p. 256
Piyush Verma, Shiwangi Kanaujia, Ashutosh K Pathak
DOI:10.4103/jism.jism_75_22  
Introduction: Low back pain affects 70–85% of the adult population at some point in life. In total 45–75% of patients continue to experience pain after 12 months of onset. Low back pain is a major health hazard in today’s technological era. The history of low back pain is as ancient as human civilization. There are pieces of evidence of low back pain and sciatica in the past era, which was a problematic concern for the population of that time. There was a practical approach of different cultures toward the low back and sciatic pain at that time. The rich history of Indian medicine guides us to the classic developments and thoughts of that era. Aims and Objectives: This study aims to illuminate descriptions and understandings of low back pain from previous historical reviews as well as fill gaps in previous reviews that ignored the hidden knowledge of low back pain from ancient Indian literature. Materials and Methods: Here published scientific articles in reputed journals regarding the historical background of low back pain, sciatica, and lumbar radiculopathy have been reviewed from PubMed, Google Scholar, Scopus, and so on, and low back pain conditions from ayurveda classics have been extracted and conceptual understanding to low back pain by ancient Indian ayurvedic scholars have been revealed. The lacunae in previous reviews of missing the knowledge of ancient Indian ayurvedic texts have been tried to fill by this work. Observations and Results: The review showed that the understanding of various conditions associated with low back pain such as katishoola, katigraha, gridhrasi, trikshoola, trikvedna, and so on. and its pathophysiology was well developed in ancient Indian culture. Conclusion: Numerous earlier studies on low back and sciatic pain have overlooked the historical significance of the Indian subcontinent. The existing information must therefore be revealed along with these crucial descriptions. The world’s focus will be directed toward ayurvedic medicines and low back pain management solutions when the concepts of ayurveda are revealed historically. As a result, this article will aid in promoting the traditional Ayurvedic medical method.
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CASE REPORTS Top

Indigestion-induced hyperacidity (Vidagdhajirna) treated with Ayurveda therapy: A single case study p. 265
Sunny C Patil, Arjun S Baghel, Shubhangi B Kamble
DOI:10.4103/jism.jism_57_22  
Ayurveda, the ancient traditional system of medicine, believes that a majority of the diseases in humans arise due to hypofunctioning of Agni (~digestive fire). Disturbed function of Agni causing indigestion of food is termed as Ajirna (~indigestion) in Ayurveda. Vidagdhajirna is one of the types of Ajirna having Pitta predominance in its manifestation. Vidagdhajirna can be compared with indigestion-induced hyperacidity because of the resemblance in signs and symptoms observed in both the conditions. In this report, we are presenting a case of a 32-year-old female patient diagnosed with Vidagdhajirna. This case was treated with Ayurveda Shamana therapy prescribed at a specific drug administration time along with cessation of known etiological factors. Therapeutic assessment was done by using Reflux Disease Questionnaire (RDQ) scale. Significant improvement was noted in clinical parameters as well as on the standard RDQ scale without reported relapse of previous symptoms on follow-up visit. Also, there were no adverse events recorded during the treatment and follow-up period.
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Effect of Yogic management with Ayurveda regimen in underweight: a case report p. 271
Rohini M Kendre, Sumeeta S Jain
DOI:10.4103/jism.jism_44_22  
Nowadays, everyone is conscious of body fitness and bodybuilding. People experiment with their body by exercising in the gym with heavy workout and with different diet plans. These experiments result in an adverse effect. In this case study, a 27-year-old male patient, lean built since childhood, with low body mass index (BMI), wanted to increase his weight. We took a detailed history to find out the exact cause. The patient was taking an extra amount of food for weight gaining, but because of the slow digestive fire, there was no positive effect of food seen; rather, the patient suffered adverse effects such as sour belching, anorexia, and indigestion. The cause of slow digestion cured with the help of Vaman Dhauti (Yogic therapeutic self-induced emesis) that helped in body detoxification. Drug therapy with do’s and don’ts were advised for 30 days, which subsided Pitta vitiation and increased appetite by increasing digestive fire. After that, the patient needs to take more quantity of food but should be balanced, so a diet plan, Yoga, and Pranayama were explained for the next 60 days. The result was a remarkable improvement in subjective symptoms as well as the weight of the patient increased from 50 kg to 58 kg and the BMI increased from 17.7 (underweight) to 20.5 (normal). With the help of traditional knowledge, we can achieve our targets to live happily and confidently. The combination of Yogic procedures (an easier method for the cleansing body) with Ayurveda principles results in remarkable improvement without adverse effects. This study has a unique intervention; lean patients also need to detoxify their body first for a better relief, then the medication will work out, which needs to be studied on a large scale.
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Management of hypothyroidism with the help of principles of Anukta disease concept: A case study p. 276
Amruta Rajendra Suryawanshi, Prasad Vitthal Kulkarni
DOI:10.4103/jism.jism_36_22  
Lack of thyroid hormone and resistance of the body tissue to thyroid hormone with respect to metabolic demand result in disorder called hypothyroidism. As per conventional science, Synthetic thyroid hormone used to manage hypothyroidism makes the patient drug dependent and still not helping in resolving underlying pathology. Hence Ayurveda is opted for study and to manage the conditions like hypothyroidism by means of Ayurvedic principle like anukta vyadhi vichar (Unstated Disease Concept): In this case, a female patient of age 35 yrs old had complainets of shwasakashtata (Breathlessness), mukhashotha (facial puffiness), hrudadrava (Palpitations), daurbalya (Weakness) was examined thoroughly with the help of ayurvedic methodology aspect like Dashavidha pariksha as patient has kaphapitta pradhan hetu and lakshana hence diagnosed as kaphaj pandu awastha as stated in classics. Treatment protocol given in samhita for this particularly diagnosed kaphaj pandu awastha which is samshodhana (Purification), Snehana (oleation) and shamana (internal medicines) was followed and successfully treated. Symptomatic relief and to wean the patient off the synthetic hormone supplement are the intent to treat the condition of hypothyroidism in this patient. This case study concludes that by means principle of Anukta vyadhi vichar, one can diagnose and successfully manage the conditions like hypothyroidism which are not stated in ayurvedic classics.
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SHORT COMMUNICATIONS Top

“Kriyanveshan 2022”: A national webinar on scope of research on fundamentals of Ayurveda p. 281
Pradnya D Dandekar, Swapnali Mate
DOI:10.4103/jism.jism_95_22  
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Celebration of 7th National Ayurveda Day p. 284
Premkumar P Badwaik
DOI:10.4103/jism.jism_98_22  
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National webinar on newer teaching–learning methods and assessment modules in Ayurved education p. 287
Amol Madhav Deshpande, Gaurav Sawarkar
DOI:10.4103/jism.jism_100_22  
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