Ayurveda is an approach to living in harmony with the universe in order to achieve optimum health. It is built on solid therotical and experimental foundation which provide a profound understanding of the physical and biological laws that govern human physiology. Panchamahabhutas (Earth, Water, Fire, Air, Ether) are building blocks of nature and body, having specific qualities and unique characteristics. They are important factors of the body, responsible for physiogical functions and in the pathogenesis of disease. Panchamahabhuta Siddhant (Principle of five basic elements) is one of the fundamental principle of Ayurveda, but still satisfactory work is not done regarding its clinical, therapautic importance. In this perception present attempt is emphasised on clinical application of Panchamahabhuta Siddhant specifically in Panchakarma (pentabio- purification) therapy. To elaborate the concept, detail literature in the form of classics, desertation, regarding Panchamahabhuta theory, its application, concept of Panchakarma and review articles available are reviewed. This conceptual study concludes that with through knowledge of Panchamahabhuta theory one can take into account Panchamahabhuta Siddhant as a basic concept in Panchakarma therapy because Panchamahabhutas are the causative factors in the imbalance of Tridoshas.. (Three functional factors of body mentioned in Ayurveda i.e. Vata, Pitta and Kapha).

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Background: More than 50% of diabetes people from India have poor glycemic control, uncontrolled hypertension, and dyslipidemia and a large percentage have diabetic vascular complications. Several types of glucose-lowering drugs are available in the market have some disadvantages. Therefore most of the people from world prefer the herbal medicine. Insulin plant (Chamaecostus cuspidatus (Nees & Mart.) C.D.Specht & D.W.Stev / Costus igneus N.E.Br.) and Haridra (Curcuma longa Linn) has been reported for diabetes, present study is the effort for scientific evaluation to assess their efficacy. Objectives: To evaluate the anti-hyperglycemic activity of Insulin plant (Costus igneus N.E.Br.) leaves and unprocessed rhizome of Haridra (Curcuma longa Linn). Materials and Method: Diabetes induced in rabbits by dexomethsone at 10mg/kg dose. Diabetes induced Rabbits from two groups were treated by powder of Insulin plant leaves and unprocessed rhizome of Curcuma longa respectively at the dose of 250mg/kg. Before treatment and after treatment blood glucose of each group were determined and compared. Results: There was a significant (p=0.0001) decrease in the blood glucose level in both groups. Unprocessed Haridra shows significant (p= 0.0109) decrease in the blood glucose level as compare to insulin plant leaves. Conclusions: Unprocessed Haridra shows potent anti-hyperglycemic activity

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An allergy is a hypersensitivity disorder of the immune system. Due to modernization & industrialization today’s lifestyle is far removed from the rules of the nature. The intake of canned food, intoxicating beverages, eating and sleeping at irregular intervals, usage of various types of synthetic drugs decline the immunity day by day which ultimately results in Allergy. Concept of Dooshivisha in Ayurveda is very unique and applicable to present condition of the universe. It is the remnant part of Sthavara(vegetative) Jangama(animate) & Kritrima visha (artificial) which enters the body and vitiates Dhatu when conditions are favorable. Harmful effects produce due to Dooshivisha are similar as that of hypersensitivity reactions. It remains in Dhatus (tissues) and on vitiation produces hazardous consequences on the body. Dooshivishari Agad is one of the formulations for treatment of Dooshivisha. Asaetio-pathogenesis of Allergy & Dooshivisha is same Dooshivishari Agad may beuseful in the management of Allergic diseases. so this review is taken to evaluate efficacy of Dooshivishari Agad in Allergy

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The incidence of Diabetes Mellitus has increased tremendously in the last decades. Advanced researches are still going on globally for the management of the disease. As the disease is mainly categorized under non infectious, endocrine, life style disorder its management needs multidimensional view and integrated approach towards the disease. Diabetes and its complications pose a major threat to future public health resources throughout the world. The disease Prameha described in Ayurvedic texts has variety of symptoms according to its types. Its etiology and main symptoms which are Prabhootmutrata (Polyurea) and Aavilmutrata (Turbid urine) closely resemble with description of Diabetes mellitus in modern science. So Prameha can be correlated with Diabetes Mellitus in regard to causes and symptoms. In this present case study A Male patient of 35 years of age with signs and symptoms of recently diagnosed DM II was on allopathic medicines for the disease and was given Guduchi Kwatha (Tinospora cordifolia decoction) shows significant results in the signs and symptoms of the patient. After completion of 1 month treatment significant results were obtained in Symptoms of disease viz Prabhootmutrata (Polyurea) and Aavilmutrata Turbid urine). Similarly significant results were obtained in BSL F and BSL PP.

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In Ayurvedic literature Sthaulya (Obesity) is described under the title of Santarpanjanita Vyadhi (Diseases due to over nutrition) as well as Kaphaja Vikaar (Disease). Many research works were carried out on Sthaulya but less no. of works carried out comparing Vaman Karma (Process of Emesis) and Lekhana Basti (Medicated Enema containing Ayurvedic drugs for reducing weight). Considering this things present research work was planned. In this study total 66 patients were randomly distributed into two groups, as Group-A, where 32 patients were given Vaman (Emesis) and Group-B, where 34 patients were givenLekhan Basti daily for 15 days followed by Kutki Churna (Picrorhiza kurroa) in the dose of 3gms twice a day % hour before meal with warm water for 1% month in both groups. The Kutki Churna was given in both groups due to its action like Bhedan, Lekhan (Depletive) & Medo-Vasa-Sleshma Upashoshana (Desiccant of fat) as well as due to its glucoside contents such as cucurbatacin, pictrohizin, benetic acid, vanillic acid, D-mannitol, and Kutkisterol. In Group-A, 13.33% patients were Markedly Improved as well as 40 % patients were Moderately, whereas in Group-B 23.33% patients were markedly improved and 46.67% patients were moderately improved. So it was concluded that although Kutki Churna has been used as Shaman (Palliative) drug in both groups, the Vaman Karma has provided significant relief while Lekhan Basti has provided relatively better relief in the management of disease Obesity.

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Sushruta, during the ancient era has devoted separate chapter for two anorectal disorders viz. Arsha (Haemorrhoids) and Bhagadara (Fistula in ano). This evidence represents the prevalence of disease Haemorrhoid amongst the commonest ailments that afflicted mankind; however its management has remained a challenge to medical profession. Though Sushruta has described detailed Hetu of Haemorrhoid, however as lifestyle has been changed significantly therefore it is of great importance to study other causes of Haemorrhoids according to modern era. In lifestyle related diseases management Nidanparivarjan (avoiding causative factor) is as importance as medication therapy. Mithya Ahar Vihar (faulty diet and habits) are predominant of all Hetus. Hence to evaluate relevant causative factors this survey study was undertaken. This study aimed at finding out whether Mithya Ahar Vihar as most predominant Hetu/ Hetus of Haemorrhoid, which may prove as key in the prevalence of the disease as well as treatment of Haemorrhoid. This survey was done with help of specially prepared questionnaire which was filled from 75 randomly selected patients based on inclusion and exclusion criteria. Sushrutokta Hetu which are included as Mithya Ahar Vihar were found mostly always and sometimes.

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Background: Protein Energy Malnutrition (PEM) in early childhood has serious long term consequences. India contributes to 1/3^rd of severely wasted children under five in the world. There are several Ayurvedic interventions which can be effectively utilized for management of PEM such as Shramhara Dashemani Kashaya (SDK) which acts as an appetizer and has nutritional value. Objective: To evaluate the comparative efficacy of SDK syrup with and without Panchakarma procedures. Material & Methods: Children affected with Moderate Acute Malnutrition aging 1year to 6 years were selected for the present prospective work. As pilot study, total of 30 patients were enrolled divided equally into 2 groups. Group A patients received only medicines while group B received medicines alongwith Sarvanga Snehan- Swedan & Matra basti(external oleation, sudation and medicated enema)by Dashmool tail for 7 days per month up to 3 months for 21 days (Parihar kala). Patients were treated with Parasik yavani syrup-PFS with Hingwashtak churna for initial 7 days. Thereafter SDK syrup for 3 months, at a dose of 5ml twice/thrice a day as per age(calculated by Young’s formula)was given to both groups. Observation & Results: The BMI in post treatment was found significant in Group A (P<0.001) and Group B (p<0.001). Owing to additional Panchkarma procedures, Group B had shown better efficacy than Group A. However there were no significant changes in BMI Z score, weight for height and height for age % of post treatment in both groups. Conclusion: It was found that Group B was effective but not significant compared to Group A. Further research with large sample size and duration may give consolidated outcome

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Ayurved provides both preventive and curative aspect for health through Shaman (palliative) and Shodhana (purification) chikitsa (treatment). Vaman (controlled vomiting) and Virechan (medicated purgation) purification process before which Abhyantar snehapaan (oral intake of medicated ghee) is important procedure of pre-treatment. Good result of purification depends on proper intake of medicated ghee. Prakruti (Constitution) is the one that affects the anatomy, physiology and psychology of every person. Intake of medicated ghee depends on Koshtha (bowel movements) and bowel movements depends on individual constitution. Thus, there is co-relation between Snehapankala (time required for oleation), bowel movement and constitution. Acharya charaka has described Samyaka snehapan lakshanas (characteristics of proper oleation) like Vatanuloamana (passage of gases), Agnidipti (increased digestive function), Snehadvega (aversion of oleation), Purishsnigdhata (unctuousness in feces) and Angalaghava (lightness) which are used as subjective parameters and Snigdhata (unctuousness) i.e. skin sebum and Mardava (softness) i.e. skin moisture are the objective parameters which can be used more effectively to assess the (completion of proper oleation) Samyaka sneha sidhhi. With inclusive and exclusive criteria, determination of constitution of volunteers was done. Intake of medicated ghee was given to the volunteers in increasing order. Observation and examination of each volunteer done up to characteristics of proper oleation are seen. Skin moisture and sebum was measured by P.C based skin moisture and derma lab sebum application module. The data was analysed by statistics. This study is an attempt to understand the actual time required & to develop objective parameter in different constitution for proper oleation.

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